NORTHAMPTON — In the spirit of St. Patrick’s Day, officials will come together Friday to commemorate two Irish immigrants, Dominic Daley and James Halligan, who were executed in 1806 after they were wrongfully convicted of murder.

Northwestern District Attorney David Sullivan will lead the ceremony, which is set to take place shortly after the Northampton St. Patrick’s Association holds its annual breakfast also scheduled for Friday morning.

Daley and Halligan were sentenced to death by hanging after they were convicted in June 1806 of murdering Marcus Lyon. But in 1984, then-Gov. Michael Dukakis exonerated the men.

The somber ceremony, which has been held on Hospital Hill for the past six decades, will take place 10 a.m. Friday.

Sullivan, who will be accompanied by former Judge W. Michael Ryan and Bill O’Riordan, a justice of the peace, is expected to speak out against the death penalty and pledge support to immigrants and refugees.

Daley and Halligan were en route to New Haven, Conneticut from Boston when they were arrested in November 1805 shortly after the Lyon’s body was found in Wilbraham. Prosecutors spent almost half a year preparing its case against the men, yet the two didn’t have counsel from a defense attorney until just two days before the trial, according to Historic Northampton.

The men were targeted, historians say, because of their Irish origins. Anti-Irish sentiments were prevalent in New England states at the time.

The now infamous trial even became the subject of a novel, “The Garden of Martyrs,” and later an opera by the same name, which was performed at the Academy of Music in September 2013.

“The trial and execution of Dominic Daley and James Halligan are reminders that we must constantly guard against the intrusion of fear and prejudice in all judicial and governmental decisions, and to resolve to not allow the rights of any racial, ethnic or religious group to be denied or infringed as a result of such prejudices,” Dukakis wrote in the proclamation at at the time.

Both Ryan and O’Riordan, according to the district attorney’s office, have each participated in the ceremony for six decades.

Additionally, in honor of St. Patrick’s Day, the Valley will play host to a number of commemorative events and celebrations, culminating with the annual parade Sunday in Holyoke.

On Friday at the Hotel Northampton, roughly 240 people will attend the 37th annual St. Patrick’s Breakfast. The popular breakfast will take place from 7 to 9 a.m. and is organized by the Northampton St. Patrick’s Association. Principal organizer Thomas Dunphy said Wednesday that this was “the hottest ticket in town.”

Former state representative Edward McColgan, who was selected as this year’s parade grand marshal, will also attend the breakfast, Dunphy added.

Come Sunday, McColgan will lead the Northampton contingent in Holyoke’s St. Patrick’s Day Parade. The parade is slated to begin at 11 a.m. in the area of the Kmart plaza.

Official festivities are expected to wrap by 2 p.m., according to the event’s website.